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PB-22 and 5F-PB-22 were being the 1st synthetic cannabinoids to include a quinoline substructure and an ester linkage. These compounds are imagined to are synthesized Along with the intention of making a synthetic cannabinoid prodrug, which could enhance absorption and confound detection. Ester bonds are conveniently biodegradable by means of spontaneous or endogenous, nonspecific esterase hydrolysis, that has been commonly used in medicinal chemistry to produce ester prodrugs.